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Chinese Journal of Natural Medicines (English Ed.) ; (6): 801-807, 2015.
Article in English | WPRIM | ID: wpr-812478

ABSTRACT

Estrogen receptor beta (ERβ) is one of the two key receptors (ERα, ERβ) that facilitate biological actions of 17β-estradiol (E2). ERβ is widely expressed in many tissues, and its expression is reduced or lost during progression of many tumors. ERβ facilitates estrogen signaling by both genomic (classical and non-classical) and extra-nuclear signaling. Emerging evidence suggests that ERβ functions as a tissue-specific tumor suppressor with anti-proliferative actions. Recent studies have identified a number of naturally available selective ERβ agonists. Targeting ERβ using its naturally available ligands is an attractive approach for treating and preventing cancers. This review presents the beneficial actions of ERβ signaling and clinical utility of several natural ERβ ligands as potential cancer therapy.


Subject(s)
Humans , Antineoplastic Agents, Phytogenic , Pharmacology , Therapeutic Uses , Equol , Pharmacology , Therapeutic Uses , Estrogen Receptor beta , Metabolism , Flavanones , Pharmacology , Therapeutic Uses , Genistein , Pharmacology , Therapeutic Uses , Glycyrrhiza , Chemistry , Ligands , Neoplasms , Drug Therapy , Metabolism , Phytotherapy , Plant Extracts , Pharmacology , Therapeutic Uses , Glycine max , Chemistry
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